GHK-Cu / KPV Blend
$75.00
Our GHK-Cu and KPV blend combines two synergistic cellular regenerative and immunomodulatory peptides in a single blend. GHK-Cu promotes extracellular matrix remodeling, collagen synthesis, and inhibits pro-inflammatory cytokine product, while KPV increases anti-inflammatory signaling by inhibiting NF-kappa-B activation without inducing melanogenic effects.
1108 in stock
What is the GHK-Cu (50MG) / KPV (10MG) Blend?
The GHK-Cu/KPV Blend is an advanced dual-peptide formulation combining the tissue modulating copper tripeptide GHK-Cu with the anti-inflammatory cytokine modulating tripeptide KPV in a single, compact 2R (3mL) glass reference vial. GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring peptide that regulates extracellular matrix (ECM) synthesis, upregulates collagen expression, and resets gene expression dermal pathways. KPV (Lys-Pro-Val) is a potent C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH) that selectively suppresses nuclear factor kappa B (NF-κB) signaling without modulating melanocortin-driven pigmentation adaptions..
Formulated by Modern Aminos, this 50MG/10MG blend provides researchers with a balanced tool to evaluate simultaneous structural matrix regeneration and acute cytokine dampening. Researchers looking to buy the GHK-Cu / KPV Blend benefit from pre-formulated peptide stoichiometry in a standardized lyophilized format, easily prepared for laboratory protocols using a specialized reconstitution solution.
Chemical and Molecular Data
| Compound Name | GHK-Cu (50MG) / KPV (10MG) Dual Blend |
|---|---|
| Quantity & Packaging | 50MG GHK-Cu + 10MG KPV (60MG Total Active Mass in 2R / 3mL Lyophilized Vial) |
| Peptide Sequences | Gly-His-Lys:Cu2+ (GHK-Cu) | Lys-Pro-Val (KPV) |
| CAS# | 49557-75-7 (GHK-Cu) | 67727-92-0 (KPV Base) |
| Chemical Formula | C14H22CuN6O4 (GHK-Cu) | C16H30N4O4 (KPV) |
| Molecular Weight | 405.90 g/mol (GHK-Cu) | 342.44 g/mol (KPV) |
| IUPAC Name | copper(2+);2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoate (GHK-Cu) and (2S)-2-[[(2S)-6-amino-2-[[(2S)-pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-methylbutanoic acid (KPV) |
| InChIKey | N/A (Multi-Peptide Complex) |
| SMILES Code | C(CCN)CC(C(=O)O)NC(=O)C(CC1=CN=CN1)NC(=O)CN.[Cu+2] (GHK-Cu)CC(C)C(C(=O)O)NC(=O)C(CCCCN)NC(=O)C1CCCN1 (KPV) |
What are the Mechanisms of Action?
The biochemical pathways and cellular targets:
- Extracellular Matrix Remodeling & Collagen Synthesis (GHK-Cu): GHK-Cu acts as a signal peptide that regulates intercellular copper transport. It stimulates the synthesis of collagen types I and III, glycosaminoglycans (GAGs), and decorin. Furthermore, it modulates matrix metalloproteinase (MMP) enzymes and their inhibitors (TIMPs), facilitating clean, non-fibrotic structural repair.
- Targeted NF-κB Suppression & Cytokine Dampening (KPV): KPV acts as a potent intracellular anti-inflammatory agent. By entering cell membranes, it directly blocks the translocation of nuclear factor kappa B (NF-κB) into the nucleus, downregulating the transcription of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 without binding melanocortin receptors that cause pigmentation modulation.
- Regenerative Synergy & Inflammatory Protection: The co-presence of GHK-Cu and KPV ensures that while GHK-Cu triggers active fibroblast proliferation and structural matrix rebuild, KPV suppresses pro-inflammatory cascades while upregulating anti-inflammatory cytokine cascades. This prevents newly synthesized collagen and matrix proteins from being degraded by hyper-active inflammatory enzymes.
What do Clinical & Preclinical Trials Show for GHK-Cu & KPV?
When evaluating research efficacy and published scientific literature for GHK-Cu and KPV:
- Gene Expression Resetting & Wound Repair (GHK-Cu): Extensive research demonstrates that GHK-Cu modulates over 4,000 genes, upregulating antioxidant pathways (DNA repair enzymes, superoxide dismutase) while downregulating pro-apoptotic genes. In vitro assays confirm accelerated keratinocyte and fibroblast migration into damaged cellular field models.
- Epithelial & Mucosal Anti-Inflammatory Assays (KPV): investigations evaluating KPV in intestinal and dermal inflammation models show that small-dose KPV significantly attenuates inflammatory cell infiltration, restores tight junction protein integrity, and reduces tissue edema independently of systemic steroid pathways.
- Formulation Stability in 2R Vials: Analytical testing confirms that co-lyophilizing GHK-Cu and KPV in a high-density 50MG:10MG ratio inside a compact 2R (3mL) glass vial maintains structural stability, prevents peptide cross-aggregation, and yields high reconstitution solubility.
How does the Blend compare to other compounds?
To evaluate functional spectrums, matrix remodeling, and anti-inflammatory capacity, researchers compare the GHK-Cu / KPV Blend against standalone formulations available at Modern Aminos:
| Compound / Product | Primary Target & Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| GHK-Cu (50MG) / KPV (10MG) Blend | Copper Tripeptide & α-MSH C-Terminal Tripeptide Matrix | Drives collagen/ECM remodeling via GHK-Cu while simultaneously blocking NF-κB inflammation via KPV | Dual-action matrix regeneration and anti-inflammatory modulation; ideal for evaluating dermal repair in inflamed cellular environments |
| GHK-Cu | Copper-Binding Tripeptide | Stimulates collagen, elastin, and glycosaminoglycan synthesis; modulates MMP/TIMP enzymatic balance | Focuses purely on structural matrix synthesis, skin re-epithelialization, and gene expression resetting without explicit NF-κB inhibition |
| KPV | α-MSH Tripeptide Fragment (Lys-Pro-Val) | Inhibits NF-κB nuclear translocation and suppresses pro-inflammatory IL-6 and TNF-α pathways | Focuses strictly on targeted cellular anti-inflammatory cytokine modulation and mucosal barrier protection without direct collagen stimulation |
| BPC-157 | Synthetic Gastric Pentadecapeptide | Activates VEGFR2, promotes focal adhesion kinase (FAK) signaling, and modulates nitric oxide (NO) pathways | Focuses primarily on collagen-driven reattachment, gut mucosal integrity, and vascular sprouting, operating through growth factor pathways rather than copper signaling |
Frequently Asked Questions (FAQs)
1. What is the rationale behind combining GHK-Cu and KPV in a 50MG / 10MG ratio?
Tissue repair is frequently halted by excessive pro-inflammatory cytokine cascades, which causes collagenase enzymes to break down newly synthesized extracellular matrix. GHK-Cu (50MG) drives active fibroblast proliferation and structural matrix synthesis, while KPV (10MG) blocks NF-κB inflammatory signaling, protecting newly formed collagen from inflammatory degradation.
2. Why is the 2R (3mL) vial format used for this dual-peptide blend?
A 2R glass vial (3mL volumetric capacity) provides a compact chamber for 60MG of combined lyophilized compounds. This minimizes headspace oxygen volume during freeze-drying, reducing oxidative degradation and ensuring rapid, clear reconstitution with smaller solvent volumes.
3. Does the KPV in this blend cause skin tanning or pigment changes?
No. KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of α-MSH. Unlike full-length α-MSH or synthetic melanocortin agonists like Melanotan II, KPV lacks the amino acid sequences required to activate cutaneous MC1R melanogenesis receptors, isolating its effects purely to intracellular NF-κB anti-inflammatory pathways.
4. Why is copper complexation essential for GHK-Cu activity?
The tripeptide GHK has a high affinity for copper(II) ions, forming a stable chelate complex (GHK-Cu). Copper is an essential cofactor for lysyl oxidase (an enzyme critical for collagen and elastin cross-linking) and superoxide dismutase (SOD). GHK acts as a carrier that delivers copper directly to cell surface receptors.
5. What are the proper storage protocols for this blend?
The lyophilized 2R vial should be stored sealed at -20°C for long-term preservation. Liquid solutions must be kept refrigerated at 2°C to 8°C and protected from light to maintain complete peptide structural integrity.
The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
By purchasing this product, you confirm that:
- You are a qualified professional or entity with the necessary knowledge, training, and facilities to handle chemical reagents safely and appropriately.
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Prohibited Uses
- This product is not to be used as an active pharmaceutical ingredient (API) in compounding or manufacturing drugs for human or veterinary use.
- It is strictly prohibited to use this product for administration to humans or animals under any circumstances.
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Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
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The buyer assumes full responsibility for ensuring the safe handling, storage, and use of this product. Modern Aminos is not liable for any damages, direct or indirect, resulting from improper handling, storage, or unauthorized use of this product. Furthermore, Modern Aminos reserves the right to refuse sales to any individual or entity suspected of misusing its products.
If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.
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